Papaparaskevas J, Pantazatou A, Katsandri A, Legakis N J, Avlamis A
Department of Microbiology, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Clin Microbiol Infect. 2005 Oct;11(10):820-4. doi: 10.1111/j.1469-0691.2005.01233.x.
The in-vitro activities of penicillin, ticarcillin-clavulanic acid, cefoxitin, imipenem, ertapenem, metronidazole and clindamycin were evaluated against 138 Gram-negative anaerobic isolates (82 Bacteroides fragilis group, 17 non-fragilis Bacteroides spp., 31 Prevotella spp., four Fusobacterium spp., two Veillonella spp., one Porphyromonas sp. and one Tissierella praeacuta) collected from six general hospitals in Athens, Greece. Overall rates of non-susceptibility (both resistant and intermediately-resistant) to penicillin and ticarcillin-clavulanic acid were 81.8% and 2.3%, respectively. The rates of non-susceptibility to cefoxitin and clindamycin were 30.3% and 31.1%, respectively, and that for metronidazole was 4.3% (four Prevotella spp. isolates, one Porphyromonas sp. isolate and one B. fragilis isolate). Only the single B. fragilis isolate was nim-positive by PCR. Only one B. fragilis isolate was resistant to both carbapenems tested, while six more Bacteroides spp. isolates were imipenem-susceptible and ertapenem-non-susceptible. The MIC range, MIC(50) and MIC(90) values were comparable for imipenem and ertapenem, although ertapenem MIC(90)s were one or two two-fold dilutions higher.
对从希腊雅典六家综合医院收集的138株革兰氏阴性厌氧菌（82株脆弱拟杆菌群、17株非脆弱拟杆菌属、31株普雷沃菌属、4株梭杆菌属、2株韦荣球菌属、1株卟啉单胞菌属和1株前锐梭菌）评估了青霉素、替卡西林-克拉维酸、头孢西丁、亚胺培南、厄他培南、甲硝唑和克林霉素的体外活性。对青霉素和替卡西林-克拉维酸的总体不敏感率（包括耐药和中介耐药）分别为81.8%和2.3%。对头孢西丁和克林霉素的不敏感率分别为30.3%和31.1%，甲硝唑的不敏感率为4.3%（4株普雷沃菌属分离株、1株卟啉单胞菌属分离株和1株脆弱拟杆菌分离株）。仅1株脆弱拟杆菌分离株经PCR检测呈Nim阳性。仅1株脆弱拟杆菌分离株对所测试的两种碳青霉烯类均耐药，而另有6株拟杆菌属分离株对亚胺培南敏感但对厄他培南不敏感。亚胺培南和厄他培南的MIC范围、MIC50和MIC90值相当，尽管厄他培南的MIC90高1倍或2倍稀释度。
