Muramoto Yukiko, Le Thi Quynh Mai, Phuong Lien Song, Nguyen Tung, Nguyen Thu Ha, Sakai-Tagawa Yuko, Iwatsuki-Horimoto Kiyoko, Horimoto Taisuke, Kida Hiroshi, Kawaoka Yoshihiro
International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
J Vet Med Sci. 2006 May;68(5):527-31. doi: 10.1292/jvms.68.527.
Highly pathogenic H5N1 avian influenza A viruses have been spreading among domestic poultry, wild aquatic birds, and humans in many Asian countries since 2003. The largest number of patients, to date, infected with the H5N1 viruses are in Vietnam, where these viruses continue to cause outbreaks in domestic poultry. Here, we molecularly characterized the hemagglutinin and neuraminidase genes of nine H5N1 viruses isolated between January 2004 and August 2005 from domestic poultry in Vietnam. We found that several groups of highly pathogenic H5N1 avian influenza viruses are circulating among these birds, which suggests that H5N1 viruses of different lineages have been introduced into Vietnam multiple times.
自2003年以来，高致病性H5N1甲型禽流感病毒一直在许多亚洲国家的家禽、野生水鸟和人类中传播。迄今为止，感染H5N1病毒患者数量最多的国家是越南，这些病毒在越南的家禽中持续引发疫情。在此，我们对2004年1月至2005年8月期间从越南家禽中分离出的9株H5N1病毒的血凝素和神经氨酸酶基因进行了分子特征分析。我们发现几组高致病性H5N1禽流感病毒正在这些鸟类中传播，这表明不同谱系的H5N1病毒已多次传入越南。
