Hidalgo V Soledad, Silva A Paulina, Undurraga S Fernanda, Soto I Néstor, Marinovic M María Angélica
Departamentos de Endocrinología, Hospital Clínico San Borja Arriarán, Santiago de Chile.
Rev Med Chil. 2006 Apr;134(4):475-80. doi: 10.4067/s0034-98872006000400011. Epub 2006 May 25.
Antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis is an uncommon complication of the use of propylthiouracil. When it occurs, it affects multiple organs as any systemic vasculitis. We report three females and one male, aged 30, 40, 43 and 41 years respectively, that after a lapse of 12 to 28 months of propylthiouracil use, presented clinical signs of vasculitis. All had high titers of ANCA against myeloperoxidase. In three patients, a skin biopsy confirmed the diagnosis. The condition subsided when propylthiouracil was discontinued, but one female patient required the use of prednisone.
抗中性粒细胞胞浆抗体（ANCA）阳性血管炎是使用丙硫氧嘧啶罕见的并发症。一旦发生，它会像任何系统性血管炎一样累及多个器官。我们报告了分别为30岁、40岁、43岁和41岁的三名女性和一名男性，在使用丙硫氧嘧啶12至28个月后，出现了血管炎的临床症状。所有患者抗髓过氧化物酶ANCA均呈高滴度。三名患者经皮肤活检确诊。停用丙硫氧嘧啶后病情缓解，但有一名女性患者需要使用泼尼松。
