D'Cruz D, Chesser A M, Lightowler C, Comer M, Hurst M J, Baker L R, Raine A E
Department of Rheumatology, St Bartholomew's Hospital, West Smithfield, London.
Br J Rheumatol. 1995 Nov;34(11):1090-1. doi: 10.1093/rheumatology/34.11.1090.
Two cases of antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis following treatment with propylthiouracil and carbimazole are described. Both patients had crescentic glomerulonephritis proven by renal biopsy and responded to immunosuppressive therapy and withdrawal of the anti-thyroid drugs. Though systemic vasculitis associated with propylthiouracil is reported, this is the first report to our knowledge of renal biopsy-proven vasculitis associated with either of these drugs.
本文描述了两例在使用丙硫氧嘧啶和卡比马唑治疗后发生抗中性粒细胞胞浆抗体（ANCA）阳性血管炎的病例。两名患者均经肾活检证实患有新月形肾小球肾炎，并对免疫抑制治疗及停用抗甲状腺药物有反应。虽然已有丙硫氧嘧啶相关的系统性血管炎报道，但据我们所知，这是首例经肾活检证实与这两种药物之一相关的血管炎报告。
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