Borgaonkar Mark R, Ford David C, Marshall John K, Churchill Elizabeth, Collins Stephen M
Department of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Dig Dis Sci. 2006 May;51(5):1026-32. doi: 10.1007/s10620-006-9348-1. Epub 2006 Jun 7.
The purpose of this study was to determine the incidence of postinfectious irritable bowel syndrome (IBS) among community subjects with positive stool studies. This was a prospective cohort study whereby all individuals with stool-positive acute enteric infection (AEI) were recruited from 3 health regions in Ontario, Canada. Each person completed questionnaires regarding preinfectious bowel habit and their bowel habit 3 months postinfection. Manning and Rome I criteria were used to diagnose irritable bowel syndrome. Two hundred thirty-one patients participated. Forty had preexisting IBS and were excluded. Of the remaining 191 patients, 7 developed irritable bowel syndrome, for an incidence of 3.7% (95% confidence interval: 1.0-6.3%). Fever during AEI was the only identifiable risk factor for developing postinfectious IBS (odds ratio, 11.96; P = .02). The incidence of postinfectious IBS in community subjects is 3.7%. Fever during the AEI may be an important risk factor for this condition.
本研究旨在确定粪便检查呈阳性的社区受试者中感染后肠易激综合征（IBS）的发病率。这是一项前瞻性队列研究，所有粪便阳性急性肠道感染（AEI）患者均从加拿大安大略省的3个健康区域招募。每个人都完成了关于感染前肠道习惯以及感染后3个月肠道习惯的问卷调查。采用曼宁和罗马I标准诊断肠易激综合征。231名患者参与研究。40名患者先前已患有IBS，被排除在外。在其余191名患者中，7人患上肠易激综合征，发病率为3.7%（95%置信区间：1.0 - 6.3%）。AEI期间发热是感染后IBS唯一可识别的危险因素（比值比，11.96；P = 0.02）。社区受试者中感染后IBS的发病率为3.7%。AEI期间发热可能是该病的一个重要危险因素。
