Koh Seong-Joon, Lee Dong Ho, Lee Sang Hyub, Park Young Soo, Hwang Jin Hyeok, Kim Jin Wook, Jeong Sook Hyang, Kim Nayoung, Im Jong Pil, Kim Joo Sung, Jung Hyun Chae
Epidemic Intelligence Service, Division of Public Health Policy, Gyeonggi Provincial Office, South Korea.
Korean J Gastroenterol. 2012 Jul;60(1):13-8. doi: 10.4166/kjg.2012.60.1.13.
BACKGROUND/AIMS: The aim of this study was to investigate the incidence and risk factors of irritable bowel syndrome (IBS) in community subjects with culture-proven bacterial gastroenteritis.
This was a prospective, community-based, cohort study, which followed patients with a recent history of culture-proven bacterial gastroenteritis. IBS was diagnosed with the use of the Rome II criteria at 3 and 6 months after bacterial dysentery.
Sixty five cases were included and completed the 6 month follow-up. Thirty four cases (52.3%) were female. Salmonella was the pathogen most frequently identified and seen in 41 patients (63.1%). The cumulative incidence of IBS among patients with microbiologically proven bacterial gastroenteritis within a community was 9.2% and 12.3% at 3 and 6 months of follow-up, respectively. The duration of initial diarrhea (≥ 7 days) was associated with an increased risk for the development of IBS (aOR, 14.50 [95% CI, 1.38-152.72]; p=0.022).
Our study suggests that the incidence of IBS among patients with culture-proven bacterial gastroenteritis within a community is similar to that reported among Western populations. A large, prospective study is encouraged to confirm our results and to evaluate the influence of the microbial species on the epidemiology of IBS in Asian populations.
背景/目的：本研究旨在调查经培养证实患有细菌性肠胃炎的社区受试者中肠易激综合征（IBS）的发病率及危险因素。
这是一项基于社区的前瞻性队列研究，对近期有经培养证实的细菌性肠胃炎病史的患者进行随访。在细菌性痢疾发生后的3个月和6个月，采用罗马II标准诊断IBS。
纳入65例患者并完成了6个月的随访。其中34例（52.3%）为女性。沙门氏菌是最常鉴定出的病原体，41例患者（63.1%）感染该菌。在社区中，经微生物学证实患有细菌性肠胃炎的患者中，IBS的累积发病率在随访3个月和6个月时分别为9.2%和12.3%。初始腹泻持续时间（≥7天）与IBS发生风险增加相关（调整后的比值比，14.50 [95%可信区间，1.38 - 152.72]；p = 0.022）。
我们的研究表明，社区中经培养证实患有细菌性肠胃炎的患者中IBS的发病率与西方人群的报告发病率相似。鼓励开展大规模前瞻性研究以证实我们的结果，并评估微生物种类对亚洲人群IBS流行病学的影响。
