Robb Paul A, Williams Daniel B, Robins Jared C, Thomas Michael A
Medical College of Wisconsin, 9200 W Wisconsin Ave., Dept. OB/Gyne, Milwaukee, WI 53226, USA.
J Assist Reprod Genet. 2006 Apr;23(4):157-60. doi: 10.1007/s10815-006-9048-y. Epub 2006 May 20.
To report a trizygotic quintuplet pregnancy following simultaneous embryo splitting in an oocyte donation cycle after transfer of 3 embryos.
A 40-year-old Caucasian female G3P1 with two previous spontaneous abortions and diminished ovarian reserve presented for IVF. The patient underwent an oocyte donation cycle secondary to diminished ovarian reserve. Three embryos were transferred per patient request.
The three embryo transfer resulted in a trizygotic quintuplet pregnancy. Selective embryo reduction was performed at 11 weeks leaving a dizygotic twin gestation. The patient underwent SVD, or spontaneous vaginal delivery at 36 weeks gestation with respective weights and apgars of 2673 g (apgars 7(1), 9(5)) and 2722 g (apgars 7(1), 9(5)). The twins are presently doing well without complications.
Although rare, the possibility of simultaneous embryo splitting must be factored into determining number of embryos for fresh transfer.
报告在3个胚胎移植后的卵母细胞捐赠周期中，通过同时胚胎分裂产生的三卵性五胞胎妊娠。
一名40岁的白种女性，G3P1，既往有两次自然流产史且卵巢储备功能减退，前来接受体外受精。由于卵巢储备功能减退，患者接受了卵母细胞捐赠周期。根据患者要求，每次移植3个胚胎。
3个胚胎移植导致三卵性五胞胎妊娠。在孕11周时进行了选择性减胎，留下双卵双胎妊娠。患者在孕36周时自然阴道分娩，出生体重分别为2673克（阿氏评分7（1分钟），9（5分钟））和2722克（阿氏评分7（1分钟），9（5分钟））。这对双胞胎目前情况良好，无并发症。
尽管罕见，但在确定新鲜移植胚胎数量时，必须考虑同时胚胎分裂的可能性。
