女性受试者腰椎骨髓血流灌注与脂质水含量之间的相关性。

Correlation between the bone marrow blood perfusion and lipid water content on the lumbar spine in female subjects.

作者信息

Chen Wei-Tsung, Shih Tiffany Ting-Fang

机构信息

Department of Radiology, Taipei Municipal Jen-Ai Hospital, Taipei, Taiwan.

出版信息

J Magn Reson Imaging. 2006 Jul;24(1):176-81. doi: 10.1002/jmri.20611.

DOI:10.1002/jmri.20611

PMID:16758477

Abstract

PURPOSE

To assess the marrow lipid water ratio (LWR) and spectral line width (LW) of lumbar vertebra by proton MR spectroscopy ((1)H MRS) and correlate with the marrow blood perfusion (MBP) by contrast-enhanced dynamic MRI (dMRI) in female subjects.

MATERIALS AND METHODS

A total of 50 female subjects were included. Single-voxel (1)H MRS was measured at the L3 vertebrae. In the dMRI study, the maximum enhancement percentage (E(max)) and enhancement slope were calculated from time-intensity curves. Pearson's correlation was calculated to explore the association of (1)H MRS, age, and perfusion parameters. Partial correlation was then used to control confounder effect.

RESULTS

LWR was negatively correlated with E(max) (r = -0.72; P < 0.0001), but positively correlated with age (r = 0.63; P < 0.0001). Lipid LW was negatively correlated with age (r = -0.33; P <0.05), but positively correlated with E(max) (r = 0.4; P < 0.05). After adjusting for the age effect by partial correlation, marrow LWR still negatively correlated with E(max) (r = -0.63; P < 0.0001). After adjusting for the E(max) effect, marrow LWR still positively correlated with age (r = 0.37; P < 0.05).

CONCLUSION

After controlling the age factor, the LWR and water LW has significant negative correlation with vertebral BMP. Further investigation is needed to explore the relationship between bone marrow fat metabolism and angiogenesis.

摘要

目的

通过质子磁共振波谱（¹H MRS）评估女性受试者腰椎骨髓脂质水比率（LWR）和谱线宽度（LW），并与对比增强动态磁共振成像（dMRI）测量的骨髓血灌注（MBP）进行相关性分析。

材料与方法

共纳入50名女性受试者。在L3椎体进行单体素质子磁共振波谱测量。在dMRI研究中，从时间-强度曲线计算最大增强百分比（E(max)）和增强斜率。计算Pearson相关性以探讨¹H MRS、年龄和灌注参数之间的关联。然后使用偏相关性来控制混杂效应。

结果

LWR与E(max)呈负相关（r = -0.72；P < 0.0001），但与年龄呈正相关（r = 0.63；P < 0.0001）。脂质LW与年龄呈负相关（r = -0.33；P <0.05），但与E(max)呈正相关（r = 0.4；P < 0.05）。通过偏相关性校正年龄效应后，骨髓LWR仍与E(max)呈负相关（r = -0.63；P < 0.0001）。校正E(max)效应后，骨髓LWR仍与年龄呈正相关（r = 0.37；P < 0.05）。