Babsky Andriy M, Hekmatyar S K, Zhang Hong, Solomon James L, Bansal Navin
Indiana Center for Excellence in Biomedical Imaging, Department of Radiology, Indiana University, Indianapolis, Indiana, USA.
J Magn Reson Imaging. 2006 Jul;24(1):132-9. doi: 10.1002/jmri.20615.
To examine the effects of the alkylating anticancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on (23)Na MRI and the water apparent diffusion coefficient (ADC) in subcutaneously- (sc-) implanted 9L glioma in rats.
(23)Na MRI and (1)H water ADC measurements were performed on sham-treated control (N = 6) and BCNU-treated (N = 15) Fisher rats one day before BCNU injection and then one, three, and five days after BCNU injection.
The BCNU-treated tumors were divided into BCNU-responsive (R(BCNU)) and BCNU-nonresponsive (NR(BCNU)) groups depending on the tumor volume changes that occurred after therapy. The pretreatment (23)Na MRI signal intensity (SI) and water ADC values were higher in R(BCNU) tumors compared to NR(BCNU) tumors. (23)Na MRI SI and water ADC increased with tumor growth in control and NR(BCNU) groups, but these changes were interrupted by BCNU therapy in R(BCNU) group.
(23)Na MRI and water ADC measurements may be useful for predicting and monitoring response to chemotherapy in some tumors. However, the changes that occurred in (23)Na MRI SI and water ADC in sc-implanted 9L tumors are in contrast to previously published results for BCNU therapy of orthotopic 9L tumors. This may have important implications for monitoring therapy response in tumors.
研究烷化剂抗癌药物1,3-双（2-氯乙基）-1-亚硝基脲（BCNU）对大鼠皮下植入的9L胶质瘤的（23）Na磁共振成像（MRI）及水表观扩散系数（ADC）的影响。
在BCNU注射前一天以及注射后1天、3天和5天，对假处理对照组（N = 6）和BCNU处理组（N = 15）的Fisher大鼠进行（23）Na MRI和（1）H水ADC测量。
根据治疗后肿瘤体积变化，将BCNU处理的肿瘤分为BCNU反应性（R(BCNU)）和BCNU无反应性（NR(BCNU)）组。与NR(BCNU)肿瘤相比，R(BCNU)肿瘤的预处理（23）Na MRI信号强度（SI）和水ADC值更高。在对照组和NR(BCNU)组中，（23）Na MRI SI和水ADC随肿瘤生长而增加，但在R(BCNU)组中，这些变化被BCNU治疗中断。
（23）Na MRI和水ADC测量可能有助于预测和监测某些肿瘤对化疗的反应。然而，皮下植入的9L肿瘤中（23）Na MRI SI和水ADC发生的变化与先前发表的原位9L肿瘤BCNU治疗结果相反。这可能对监测肿瘤治疗反应具有重要意义。
