激光能量密度在皮肤放射性损伤光动力治疗中的作用

Role of laser energy density for photodynamic therapy of radiation injuries of the skin.

作者信息

Nikitina R G, Kaplan M A, Morozova T G, Drozhzhina V V, Epatova T V, Luk'yanova E Yu

机构信息

Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk.

出版信息

Bull Exp Biol Med. 2005 Nov;140(5):558-60. doi: 10.1007/s10517-006-0023-5.

DOI:10.1007/s10517-006-0023-5

PMID:16758624

Abstract

The role of different laser energy densities used in photodynamic therapy in the reparation of radiation ulcers caused by X-ray exposure in a dose of 80 Gy was studied. Tissue reparation manifested differently at different laser energy densities. After photodynamic therapy at energy density of 0.1 J/cm2 the rate of healing was notably higher during early periods. After exposure at 5 and 40 J/cm2 acceleration of ulcer healing was observed 14 and more days after the treatment, indicating the emergence of another mechanism of photodynamic therapy effect. Laser energy density of 5 J/cm2 was the most effective for maximally complete healing of radiation ulcers.

摘要

研究了光动力疗法中使用的不同激光能量密度在修复80 Gy剂量X射线照射所致放射性溃疡中的作用。在不同的激光能量密度下，组织修复表现不同。在能量密度为0.1 J/cm²的光动力疗法后，早期愈合速度明显更高。在5和40 J/cm²照射后，治疗14天及更久后观察到溃疡愈合加速，表明出现了光动力疗法作用的另一种机制。5 J/cm²的激光能量密度对放射性溃疡的最大程度完全愈合最有效。