Kitiashvili I Z, Burov N E, Freĭdlin I S, Khrykova E V
Anesteziol Reanimatol. 2006 Mar-Apr(2):4-9.
Immunological parameters were studied at randomization in 60 surgical patients during the similar operation--cholecystectomy made under combined endotracheal low-flow general anesthesia using N2O:O2+fentanyl in 32 patients and Xe:O2 in 28 patients. The time course of changes in cellular immunity and cytokines was closely related to the type of an anesthetic. Unlike N2O:O2+fentanyl, Xe did not show such a marked proinflammatory activity, exerted a mild normalizing effect on leuko- and lymphopoiesis, had an immunostimulating activity, and reduced the frequency of postoperative inflammatory complications and the length of stay at hospital. The differences in the action of the anesthetics were due to the fact that Xe had a greater narcotic potential, a protective action on neuroendocrine function, and no toxicity. Xe is indicated to patients with baseline immunodeficiency.
在60例接受类似手术（胆囊切除术）的外科患者中，在随机分组时研究了免疫参数。32例患者在气管内低流量全身麻醉联合使用N2O:O2+芬太尼的情况下进行手术，28例患者在Xe:O2麻醉下进行手术。细胞免疫和细胞因子的变化时间过程与麻醉类型密切相关。与N2O:O2+芬太尼不同，Xe没有表现出如此明显的促炎活性，对白细胞生成和淋巴细胞生成有轻度的正常化作用，具有免疫刺激活性，并降低了术后炎症并发症的发生率和住院时间。麻醉剂作用的差异是由于Xe具有更大的麻醉潜力、对神经内分泌功能的保护作用且无毒性。Xe适用于基线免疫缺陷患者。
