Sarkar Shubhashish, Wise Kimberly C, Manna Sunil K, Ramesh Vani, Yamauchi Keiko, Thomas Renard L, Wilson Bobby L, Kulkarni Anil D, Pellis Neil R, Ramesh Govindarajan T
Molecular Neurotoxicology Laboratory/Proteomics, Department of Biology, Texas Southern University, Houston, Texas 77004, USA.
In Vitro Cell Dev Biol Anim. 2006 Mar-Apr;42(3-4):96-9. doi: 10.1290/0512083.1.
Microgravity induces stress, and the brain is one of the targets that is more influenced in this environment. Alteration in transcription factors can have enormous effect because of discrepancy in the signaling process of the cells. Activator protein-1 (AP-1) is a stress-regulated transcription factor and is involved in the regulation of physiological and pathological stimuli that include cytokines, growth factors, and stress signals. In the present study, an attempt has been made to observe the effect of a microgravity environment on the activation of AP-1 in the mouse brain. Our results show that AP-1 transcription factor is activated in simulated microgravity conditions in different regions of the brain. The activation of the AP-1 is dependent upon the increased kinase activity of c-Jun NH-terminal2 kinase-1. These results suggest that microgravity stress in the brain can elicit AP-1 activity.
微重力会引发应激反应，而大脑是在这种环境中受影响较大的靶器官之一。由于细胞信号传导过程存在差异，转录因子的改变可能会产生巨大影响。活化蛋白-1（AP-1）是一种受应激调节的转录因子，参与包括细胞因子、生长因子和应激信号在内的生理和病理刺激的调节。在本研究中，我们试图观察微重力环境对小鼠大脑中AP-1激活的影响。我们的结果表明，在模拟微重力条件下，大脑不同区域的AP-1转录因子被激活。AP-1的激活依赖于c-Jun氨基末端激酶-1激酶活性的增加。这些结果表明，大脑中的微重力应激可引发AP-1活性。
