Cai Hou-rong, Cao Min, Meng Fan-qing, Wei Jing-yi, Hou Jie
Department of Pulmonary Medicine, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, Nanjing 210008, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2006 May;29(5):313-6.
To highlight the characteristics of giant cell interstitial pneumonia (GIP).
The clinical, radiological and pathological data of a patient with GIP confirmed by open lung biopsy were presented, and relevant literatures were reviewed.
Patients with GIP usually had a history of exposure to metal dust. Clinical presentations include cough and dyspnea on exertion, and pulmonary function testing showed a restrictive abnormality. On chest radiography and high-resolution CT scans, it presents as bilateral areas of ground-glass attenuation, areas of consolidation, diffuse small nodules, extensive reticular opacities and traction bronchiectasis. The main pathological findings include a desquamative interstitial pneumonia (DIP)-like reaction with intra-alveolar macrophages and numerous large multinucleated histiocytes that ingested inflammatory cells were admixed with macrophages. The finding of GIP is almost pathognomonic for hard metal pneumoconiosis.
GIP is a very rare chronic interstitial pneumonia, and has no characteristic clinical manifestations. Radiographic findings are similar to other idiopathic interstitial pneumonias. Meticulous history taking on occupational exposure is important for the diagnosis of GIP.
强调巨细胞间质性肺炎（GIP）的特征。
呈现1例经开胸肺活检确诊为GIP患者的临床、影像学和病理资料，并复习相关文献。
GIP患者通常有接触金属粉尘的病史。临床表现包括咳嗽和劳力性呼吸困难，肺功能检查显示限制性异常。胸部X线和高分辨率CT扫描表现为双侧磨玻璃样密度减低区、实变区、弥漫性小结节、广泛的网状阴影和牵拉性支气管扩张。主要病理表现包括脱屑性间质性肺炎（DIP）样反应，肺泡内有巨噬细胞，大量吞噬炎性细胞的大的多核组织细胞与巨噬细胞混合存在。GIP的表现几乎是硬金属尘肺的特征性表现。
GIP是一种非常罕见的慢性间质性肺炎，无特征性临床表现。影像学表现与其他特发性间质性肺炎相似。详细询问职业暴露史对GIP的诊断很重要。
