与豚鼠相比，多氯联苯处理和未处理的仓鸮（Tyto alba）及沼泽龟（Mauremys caspica）肾上腺微粒体中细胞色素P-450介导的孕酮代谢

Cytochrome P-450 mediated metabolism of progesterone by adrenal microsomes of PCB-treated and untreated barn owl (Tyto alba) and marsh turtle (Mauremys caspica) in comparison with the guinea-pig.

Goldman D, Yawetz A

Institute for Nature Conservation Research, George S. Wise Faculty for Life Sciences, Tel Aviv University, Ramat Aviv, Israel.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;99(1-2):251-5. doi: 10.1016/0742-8413(91)90107-5.

Abstract

Significant differences between species were observed in the profile of steroids produced from progesterone by adrenal microsomes as well as in the effects elicited by Aroclor 1254 on cytochrome P-450-mediated activities. 2. In the guinea-pig, the major metabolites were products of the corticosteroid pathway but products of the androgenic pathway were also detected; in the barn owl products of both pathways were also formed while in the marsh turtle only products of the corticosteroid pathway were detected. 3. The effect of Aroclor 1254 on P-450C21 activity in the turtle and barn owl was inductive in contrast to the inhibitory effect observed in the guinea-pig.

摘要

观察到不同物种之间在肾上腺微粒体由孕酮产生的甾体谱以及艾氏剂1254对细胞色素P - 450介导活性所引发的效应方面存在显著差异。2. 在豚鼠中，主要代谢产物是皮质类固醇途径的产物，但也检测到了雄激素途径的产物；在仓鸮中，两种途径的产物都有形成，而在沼泽龟中只检测到了皮质类固醇途径的产物。3. 与在豚鼠中观察到的抑制作用相反，艾氏剂1254对龟和仓鸮中P - 450C21活性的影响是诱导性的。