雏仓鸮和雏鸡混合功能氧化酶系统的产后发育以及Aroclor 1254对成熟个体中该系统的诱导作用。

Postnatal development of the mixed function oxidase system in nestling barn owls and baby chicks and induction of this system in the mature forms by Aroclor 1254.

作者信息

Rinzky A, Perry A S

出版信息

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1983;75(1):51-5. doi: 10.1016/0742-8413(83)90011-7.

Abstract

Postnatal changes in content and activity of the mixed-function oxidase system in nestling barn owls and baby chicks showed the following: 1. Increase in liver weight in both. 2. Significantly higher cytochrome P-450 level in 1-day old chicks but lower in 1-day old owls than at any other age. 3. Ratio of cytochrome b5 to P-450 was lower than one in nestling owls but higher than one in chicks. 4. Aroclor 1254 (PCBs) increased the level and catalytic activity of cytochrome P-450 more in the owl than in the chick. 5. The ratio 455:430 nm characteristic of ethylisocyanide binding was not altered in the barn owl due to PCB treatment but changed significantly in the treated chicken.

摘要

雏仓鸮和雏鸡混合功能氧化酶系统的含量及活性在出生后的变化如下

二者肝脏重量均增加。2. 1日龄雏鸡的细胞色素P - 450水平显著高于其他任何年龄，但1日龄仓鸮的细胞色素P - 450水平低于其他任何年龄。3. 雏仓鸮中细胞色素b5与P - 450的比值低于1，而雏鸡中该比值高于1。4. 艾氏剂1254（多氯联苯）对仓鸮细胞色素P - 450水平及催化活性的提升作用比对雏鸡的更强。5. 经多氯联苯处理后，仓鸮中异氰基乙烷结合的特征比值455:430纳米未发生改变，但处理后的鸡中该比值发生了显著变化。