健康成年人中针对水痘带状疱疹病毒的记忆性T细胞免疫的变异性及性别差异。
Variability and gender differences in memory T cell immunity to varicella-zoster virus in healthy adults.
作者信息
Klein Nicola P, Holmes Tyson H, Sharp Margaret A, Heineman Thomas C, Schleiss Mark R, Bernstein David I, Kemble George, Arvin Ann M, Dekker Cornelia L
机构信息
Division of Pediatric Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305-520, USA.
出版信息
Vaccine. 2006 Aug 14;24(33-34):5913-8. doi: 10.1016/j.vaccine.2006.04.060. Epub 2006 May 9.
Latent varicella zoster virus (VZV) can reactivate and cause zoster, the prevention of which relies upon cellular immunity to VZV. To assess temporal variation of VZV cell-mediated immunity in healthy naturally immune adults, we evaluated VZV-specific responder cell frequencies (RCF) longitudinally over 1 year in each of 25 adults. VZV-specific CD4+ T cells were detected (p < 0.003) and showed minimal variability in RCF. Additional analysis of VZV T cell RCF revealed differences between genders, with only males (p < 0.005) having detectable VZV-specific memory CD4+ T cell responses by this method. Taken together, results suggest that further studies regarding immunization of younger adults and females with the modified, high-potency live attenuated VZV vaccine may be warranted.
潜伏性水痘带状疱疹病毒（VZV）可重新激活并引发带状疱疹，其预防依赖于针对VZV的细胞免疫。为评估健康自然免疫成年人中VZV细胞介导免疫的时间变化，我们在25名成年人中每人纵向评估了1年的VZV特异性应答细胞频率（RCF）。检测到VZV特异性CD4 + T细胞（p < 0.003），且RCF变化极小。对VZV T细胞RCF的进一步分析揭示了性别差异，通过该方法只有男性（p < 0.005）具有可检测到的VZV特异性记忆CD4 + T细胞应答。综合来看，结果表明可能有必要对年轻成年人和女性使用改良的高效减毒活VZV疫苗进行免疫的进一步研究。
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