Molina-Hernández Miguel, Tellez-Alcántara Norma Patricia, Pérez-García Julián, Olivera-Lopez Jorge Iván, Jaramillo M Teresa
Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1129-35. doi: 10.1016/j.pnpbp.2006.04.022. Epub 2006 Jun 8.
This study describes the effects of intra-lateral septal infusions of different doses of the mGluR5 antagonist MTEP in the DRL-72 s paradigm and the elevated plus-maze test in rats, two behavioral models known to be sensitive to antidepressant-like and anxiolytic-like drug effects, respectively. Intra-lateral septal infusions of MTEP induced a dose-dependent (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increase in reinforced lever presses and a cohesive rightward shift of the inter-response time distribution (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05). These effects are indicative of antidepressant-like actions of the compound. Desipramine, a prototypical antidepressant drug, induced (5.0 microg/microl; P<0.05) similar effects. In the elevated plus-maze test, intra-lateral septal infusions of MTEP (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increased the exploration of the open arms without affecting locomotion. This anxiolytic-like effect was similar to that observed with the infusion of the benzodiazepine midazolam (10.0 microg/microl; P<0.05) in the same brain area. It is concluded that intra-lateral septal infusions of the mGlu5 receptor antagonist MTEP produced antidepressant-like actions or anxiolytic-like effects in male rats.
本研究描述了在大鼠的固定比率72秒范式和高架十字迷宫试验中，向侧脑室注射不同剂量的亲代谢型谷氨酸受体5（mGluR5）拮抗剂2-甲基-6-(苯乙炔基)-吡啶（MTEP）的效果，这两种行为模型分别已知对类抗抑郁药和类抗焦虑药的作用敏感。向侧脑室注射MTEP可导致强化杠杆按压次数呈剂量依赖性增加（5.0微克/微升，P<0.05；10.0微克/微升，P<0.05），并且反应间期分布出现一致性右移（5.0微克/微升，P<0.05；10.0微克/微升，P<0.05）。这些效应表明该化合物具有类抗抑郁作用。典型的抗抑郁药物地昔帕明也可产生类似效应（5.0微克/微升；P<0.05）。在高架十字迷宫试验中，向侧脑室注射MTEP（5.0微克/微升，P<0.05；10.0微克/微升，P<0.05）可增加对开放臂的探索，而不影响运动。这种类抗焦虑效应与在同一脑区注射苯二氮䓬类药物咪达唑仑（10.0微克/微升；P<0.05）所观察到的效应相似。得出的结论是，向侧脑室注射mGlu5受体拮抗剂MTEP可在雄性大鼠中产生类抗抑郁作用或类抗焦虑效应。
