Jiang Ze D, Brosi Dorothea M, Wilkinson Andrew R
Children's Hospital, Shanghai Medical University, Shanghai, China.
Clin Neurophysiol. 2006 Jul;117(7):1551-9. doi: 10.1016/j.clinph.2006.04.021. Epub 2006 Jun 8.
To examine brain-stem auditory function at term in very preterm infants who suffered chronic lung disease (CLD).
Brain-stem auditory evoked response (BAER) was recorded at term with clicks in 25 very preterm infants with CLD and no concomitant other major perinatal problems.
Compared to those in normal term controls, BAER wave V latency and I-V and III-V interpeak intervals in the CLD infants increased significantly (ANOVA P<0.01-0.001). III-V/I-III interval ratio also increased significantly (P<0.01). The latencies of waves I and III did not differ significantly from the controls. However, no abnormalities were found in BAER wave amplitudes. These BAER findings, obtained at 21/s clicks, were also seen at the rates 51 and 91/s, although the increase in III-V interval tended to be more significant. Click rate-dependent changes in BAER variables in the CLD infants were generally similar to the controls, with slight differences.
BAER components, mainly reflecting central auditory function, increased significantly. The increase in wave V latency and I-V interval is due to the increase in III-V interval.
Neural conduction in the more central portion of the brain-stem auditory pathway is delayed and thus brain-stem auditory function is impaired in CLD infants.
研究患有慢性肺病（CLD）的极早产儿足月时的脑干听觉功能。
对25名患有CLD且无其他主要围产期问题的极早产儿在足月时进行短声脑干听觉诱发电位（BAER）记录。
与正常足月对照组相比，CLD婴儿的BAER波V潜伏期、I-V和III-V峰间期显著增加（方差分析P<0.01-0.001）。III-V/I-III间期比值也显著增加（P<0.01）。波I和波III的潜伏期与对照组无显著差异。然而，BAER波幅未发现异常。在21次/秒短声刺激下获得的这些BAER结果，在51次/秒和91次/秒刺激率下也可见，尽管III-V间期的增加往往更显著。CLD婴儿BAER变量的短声刺激率依赖性变化与对照组总体相似，但有细微差异。
主要反映中枢听觉功能的BAER成分显著增加。波V潜伏期和I-V间期的增加是由于III-V间期的增加。
CLD婴儿脑干听觉通路更中枢部分的神经传导延迟，因此脑干听觉功能受损。
