Takase H, Tatsumi Y, Miura O, Yumioka E, Suzuki A
Kanebo, Ltd., Kampo Research Laboratories, Osaka, Japan.
Nihon Yakurigaku Zasshi. 1991 Feb;97(2):97-103. doi: 10.1254/fpj.97.2_97.
The effect of oren-gedoku-to (OGT) on gastric acid secretion was examined in the perfused stomach of anesthetized rats. OGT (10-100 mg/kg) given intraperitoneally dose-dependently inhibited the gastric acid secretion stimulated by intracerebroventricular DN-1417, an analogue of TRH, but failed to inhibit the acid secretion stimulated by intracerebroventricular baclofen, an analogue of GABA. The inhibitory effect of OGT on DN-1417-induced acid secretion was antagonized by haloperidol (0.3 and 1.0 mg/kg, i.p.), a dopamine-1/2 antagonist or sulpiride (100 mg/kg, i.p.), a dopamine-2 antagonist; and it was also reversed by yohimbine (0.3 mg/kg, i.p.), an alpha-2 adrenergic antagonist, and prazosin, an alpha-1 antagonist. These results suggest that the ability of OGT to reduce acid secretion is mediated via not only dopamine receptors but also alpha-2 adrenoceptors.
在麻醉大鼠的灌流胃中研究了黄连解毒汤（OGT）对胃酸分泌的影响。腹腔注射OGT（10 - 100mg/kg）剂量依赖性地抑制了由脑室内注射TRH类似物DN - 1417刺激引起的胃酸分泌，但未能抑制由脑室内注射GABA类似物巴氯芬刺激引起的胃酸分泌。OGT对DN - 1417诱导的胃酸分泌的抑制作用被多巴胺1/2拮抗剂氟哌啶醇（0.3和1.0mg/kg，腹腔注射）或多巴胺2拮抗剂舒必利（100mg/kg，腹腔注射）拮抗；并且也被α - 2肾上腺素能拮抗剂育亨宾（0.3mg/kg，腹腔注射）和α - 1拮抗剂哌唑嗪逆转。这些结果表明，OGT减少胃酸分泌的能力不仅通过多巴胺受体介导，还通过α - 2肾上腺素能受体介导。
