Takase H, Imanishi K, Miura O, Yumioka E, Watanabe H
Kanebo Co., Ltd., Kampo Research Center, Osaka, Japan.
Nihon Yakurigaku Zasshi. 1988 May;91(5):309-17. doi: 10.1254/fpj.91.309.
The effects of OGT, SST, AS and DST on gastric acid secretion stimulated by histamine, pentagastrin, carbachol and 2-deoxy-D-glucose (2-DG) were studied in the perfused stomach of anesthetized rats, and these effects were compared with those of cimetidine, 16,16-dimethyl-prostaglandin E2(DMPGE2) and atropine. OGT and SST showed little or no effect on the acid secretion induced by histamine or carbachol at doses of 100 mg/kg, whereas the former showed a moderate inhibition and the latter showed a marked one against pentagastrin-stimulation. AS and DST had no effect on the acid secretion induced by carbachol at doses of 100 mg/kg, whereas they showed a moderate inhibition against histamine-stimulation, and the latter showed a significant inhibition against pentagastrin-stimulation. Further, each of the above four drugs showed a significant effect on 2-DG-stimulation. Cimetidine (1-10 mg/kg) inhibited gastric acid secretion stimulated by histamine, pentagastrin, carbachol or 2-DG in a dose-dependent manner. Similarly, DMPGE2 (10 micrograms/kg) strongly inhibited acid secretion induced by the four secretagogues. Atropine (50 micrograms/kg) inhibited acid secretion induced by carbachol or 2-DG, but not that by histamine or pentagastrin. These results suggest that OGT, SST, AS and DST clearly affect the mechanism of gastric acid secretion, and the site of action of OGT may differ from those of SST, AS and DST.
在麻醉大鼠的灌流胃中研究了OGT、SST、AS和DST对组胺、五肽胃泌素、卡巴胆碱和2-脱氧-D-葡萄糖（2-DG）刺激的胃酸分泌的影响，并将这些影响与西咪替丁、16,16-二甲基前列腺素E2（DMPGE2）和阿托品的影响进行比较。在100mg/kg剂量下，OGT和SST对组胺或卡巴胆碱诱导的胃酸分泌几乎没有影响，而前者对五肽胃泌素刺激有中度抑制作用，后者有明显抑制作用。在100mg/kg剂量下，AS和DST对卡巴胆碱诱导的胃酸分泌没有影响，而它们对组胺刺激有中度抑制作用，后者对五肽胃泌素刺激有显著抑制作用。此外，上述四种药物对2-DG刺激均有显著作用。西咪替丁（1-10mg/kg）以剂量依赖性方式抑制组胺、五肽胃泌素、卡巴胆碱或2-DG刺激的胃酸分泌。同样，DMPGE2（10μg/kg）强烈抑制四种促分泌剂诱导的胃酸分泌。阿托品（50μg/kg）抑制卡巴胆碱或2-DG诱导的胃酸分泌，但不抑制组胺或五肽胃泌素诱导的胃酸分泌。这些结果表明，OGT、SST、AS和DST明显影响胃酸分泌机制，OGT的作用部位可能与SST、AS和DST不同。
