Bogreau Hervé, Renaud François, Bouchiba Housem, Durand Patrick, Assi Serge-Brice, Henry Marie-Claire, Garnotel Eric, Pradines Bruno, Fusai Thierry, Wade Boubacar, Adehossi Eric, Parola Philippe, Kamil Mohamed Ali, Puijalon Odile, Rogier Christophe
Institut de Médecine Tropicale du Service de Santé des Armées, Unité de Recherche en Biologie et Epidémiologie Parasitaire, Marseille, France.
Am J Trop Med Hyg. 2006 Jun;74(6):953-9.
The genetic variability and population structure of Plasmodium falciparum are key factors in malaria control strategies. Studies have suggested no P. falciparum population structure although linkage disequilibrium was observed in some African areas. We have assessed length polymorphism at 6-22 microsatellites in four urban and rural sites (Djibouti, Dakar, Niamey, and Zouan-Hounien, n = 240 blood samples). Results have shown a P. falciparum population structure in Africa (Fst = 0.17-0.24), lower genetic diversity in Djibouti (He = 0.53) than in the other sites (He = 0.73-0.76), and 3) significant linkage disequilibrium in Djibouti. These results could be related to geographic isolation and low flow of parasites between sites. They also suggest a potential effect of rural suburbs to generate genetic diversity in towns. This could affect the dispersal of selected drug resistance and should be considered when adapting urban malaria control strategies.
恶性疟原虫的遗传变异性和种群结构是疟疾控制策略的关键因素。研究表明，尽管在非洲一些地区观察到连锁不平衡现象，但恶性疟原虫不存在种群结构。我们评估了四个城乡地点（吉布提、达喀尔、尼亚美和祖安胡年，n = 240份血样）中6 - 22个微卫星的长度多态性。结果显示非洲存在恶性疟原虫种群结构（Fst = 0.17 - 0.24），吉布提的遗传多样性（He = 0.53）低于其他地点（He = 0.73 - 0.76），并且3）吉布提存在显著的连锁不平衡。这些结果可能与地理隔离以及不同地点间寄生虫的低传播率有关。它们还表明农村郊区对城镇遗传多样性产生的潜在影响。这可能会影响所选耐药性的传播，在调整城市疟疾控制策略时应予以考虑。
