8-甲氧基补骨脂素在黑暗条件下对受刺激淋巴细胞增殖的影响。

Effect of 8-methoxypsoralen in the dark on proliferation of stimulated lymphocytes.

作者信息

Górski G, Antosz H, Gawron A

机构信息

Department of Medical Genetics, Medical Academy, Lublin, Poland.

出版信息

J Pharm Pharmacol. 1991 Jan;43(1):63-4. doi: 10.1111/j.2042-7158.1991.tb05454.x.

DOI:10.1111/j.2042-7158.1991.tb05454.x

PMID:1676067

Abstract

The effect of 8-methoxypsoralen (8-MOP) in the dark on proliferation of phytohaemagglutinin-stimulated human lymphocytes has been examined, using total blood leucocytes, the lymphocyte fraction and the T-lymphocyte subpopulation. 8-MOP (1 microgram mL-1) increased [3H]TdR incorporation and caused a rise in the blastic and mitotic index in all experimental cultures. The lymphocyte proliferation in these experiments was effected by a comitogenic effect of 8-MOP on T-lymphocytes.

摘要

利用全血白细胞、淋巴细胞组分和T淋巴细胞亚群，研究了8-甲氧基补骨脂素（8-MOP）在黑暗条件下对植物血凝素刺激的人淋巴细胞增殖的影响。8-MOP（1微克/毫升）增加了[3H]胸腺嘧啶核苷的掺入，并导致所有实验培养物中的母细胞化和有丝分裂指数升高。这些实验中的淋巴细胞增殖是由8-MOP对T淋巴细胞的协同有丝分裂作用所影响的。