Ramasubbu Kumudha, Oliveira Guilherme, Torre-Amione Guillermo
Section of Cardiology, Baylor College of Medicine, Houston, TX, USA.
Congest Heart Fail. 2006 May-Jun;12(3):153-9; quiz 160-1.
The understanding of the pathomechanisms leading to heart failure has evolved from the simplistic pump-failure concept to the more complex syndrome involving neurohormonal and inflammatory systems. Anti-inflammatory therapy targeting specific cytokines, however, such as tumor necrosis factor-alpha, has failed to show clinical benefit. As a result, the focus has turned toward more broad-spectrum anti-inflammatory strategies. This review examines the various broad-spectrum anti-inflammatory modalities that have been used in heart failure: IV immunoglobulin administration, immune modulation therapy, immune adsorption, and plasmapheresis.
对导致心力衰竭发病机制的理解已从简单的泵衰竭概念发展到涉及神经激素和炎症系统的更复杂综合征。然而，针对特定细胞因子（如肿瘤坏死因子-α）的抗炎治疗未能显示出临床益处。因此，重点已转向更广泛的抗炎策略。本综述探讨了在心力衰竭中使用的各种广泛抗炎方式：静脉注射免疫球蛋白、免疫调节治疗、免疫吸附和血浆置换。
