人工肺顺应性对体内肺循环系统血流动力学的影响。
Effect of artificial lung compliance on in vivo pulmonary system hemodynamics.
作者信息
Sato Hitoshi, McGillicuddy John W, Griffith Grant W, Cosnowski Amy M, Chambers Sean D, Hirschl Ronald B, Bartlett Robert H, Cook Keith E
机构信息
Department of Surgery and Bioengineering, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
ASAIO J. 2006 May-Jun;52(3):248-56. doi: 10.1097/01.mat.0000208961.67272.fa.
This study examined the effect of artificial lung compliance (C) on pulmonary system (PS) impedance and right ventricular function during in-series attachment of the MC3 Biolung in adult sheep. Compliances, C, of 0-20 ml/mm Hg were tested at the Biolung inlet. Results indicate the PS 0 harmonic input impedance modulus was not affected by C. The PS first harmonic input impedance modulus (Z1) was 10.9 +/- 3.2 mm Hg/(l/min) at C = 0 ml/mm Hg and minimized to 2.41 +/- 0.79 mm Hg/(l/min) at C > or = 0.5 ml/mm Hg. Cardiac output was 58% +/- 10% of its pre-Biolung attachment, baseline value at C = 0 ml/mm Hg and was maximized to an average of 75% +/- 11% at C > or = 0.5 ml/mm Hg. The left ventricular lateral-to-anteroposterior axis length ratio, which decreases with leftward septal shift, increased with C from 0.52 +/- 0.12 at C = 0 ml/mm Hg to 0.76 +/- 0.06 at C = 5 ml/mm Hg (p < 0.05), but decreased slightly with C at C > 5 ml/mm Hg. Therefore, the ideal C for right ventricular function is at least 0.5 ml/mm Hg and may be as high as 5 ml/mm Hg to minimize septal shift.
本研究检测了在成年绵羊体内串联连接MC3生物肺期间，人工肺顺应性（C）对肺系统（PS）阻抗和右心室功能的影响。在生物肺入口处测试了0至20 ml/mm Hg的顺应性C。结果表明，PS的0次谐波输入阻抗模量不受C的影响。在C = 0 ml/mm Hg时，PS的一次谐波输入阻抗模量（Z1）为10.9±3.2 mm Hg/（l/min），在C≥0.5 ml/mm Hg时最小化至2.41±0.79 mm Hg/（l/min）。心输出量在C = 0 ml/mm Hg时为连接生物肺前基线值的58%±10%，在C≥0.5 ml/mm Hg时最大化至平均75%±11%。左心室左右径与前后径的长度比随室间隔向左移位而减小，随C增加，从C = 0 ml/mm Hg时的0.52±0.12增加到C = 5 ml/mm Hg时的0.76±0.06（p<0.05），但在C>5 ml/mm Hg时随C略有下降。因此，对于右心室功能而言，理想的C至少为0.5 ml/mm Hg，可能高达5 ml/mm Hg，以尽量减少室间隔移位。
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