Syed Ahad, Kerdi Sarah, Qamar Adnan
Nanofabrication Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Bioengineering (Basel). 2021 Jun 28;8(7):89. doi: 10.3390/bioengineering8070089.
Artificial lung technology is advancing at a startling rate raising hopes that it would better serve the needs of those requiring respiratory support. Whether to assist the healing of an injured lung, support patients to lung transplantation, or to entirely replace native lung function, safe and effective artificial lungs are sought. After 200 years of bioengineering progress, artificial lungs are closer than ever before to meet this demand which has risen exponentially due to the COVID-19 crisis. In this review, the critical advances in the historical development of artificial lungs are detailed. The current state of affairs regarding extracorporeal membrane oxygenation, intravascular lung assists, pump-less extracorporeal lung assists, total artificial lungs, and microfluidic oxygenators are outlined.
人工肺技术正以惊人的速度发展，人们希望它能更好地满足那些需要呼吸支持的人的需求。无论是协助受伤肺部的愈合、支持患者进行肺移植，还是完全替代天然肺功能，都在寻求安全有效的人工肺。经过200年的生物工程进步，人工肺比以往任何时候都更接近满足这一需求，由于新冠疫情危机，这一需求呈指数级增长。在这篇综述中，详细介绍了人工肺历史发展中的关键进展。概述了体外膜肺氧合、血管内肺辅助、无泵体外肺辅助、全人工肺和微流控氧合器的现状。
