Zhao San-Ping, Ma Dong, Zhang Li-Ming
School of Chemistry and Chemical Engineering and Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, China.
Macromol Biosci. 2006 Jun 16;6(6):445-51. doi: 10.1002/mabi.200600011.
Amphiphilic hydrogels composed of aliphatic polyesters and poly(ethylene glycol) have potential applications in drug delivery, tissue engineering and other biomedical devices due to their advantageous biological properties, biocompatibility and biodegradability. However, they also exhibit some shortcomings in terms of their reactivity, swelling and mechanical properties. To address these limitations, new semi-interpenetrating network (semi-IPN) hydrogels based on poly(ethylene glycol)-co-poly(epsilon-caprolactone) (PEG-PCL) diacrylate macromer and hydroxypropyl guar gum (HPGG) were prepared by a low intensity ultraviolet (UV) light irradiation method, and characterized by FT-IR, DSC and WAXD analysis. Their properties were evaluated by investigating the swelling kinetics, dynamic mechanical rheology and the release behavior for bovine serum albumin (BSA). It was found that the introduction of the semi-IPN structure and HPGG decreased the crystallinity of PEG segments in the hydrogel, and improved the swelling and mechanical properties of the hydrogel, as well as lowered the release percentage of BSA from the hydrogel. Such hydrogel materials may have more advantages as a potentially interesting platform for the design of medical devices.The elastic modulus (G') and viscous modulus (G'') as a function of frequency for various hydrogel samples.
由脂肪族聚酯和聚乙二醇组成的两亲性水凝胶因其有利的生物学特性、生物相容性和生物降解性，在药物递送、组织工程和其他生物医学装置中具有潜在应用。然而，它们在反应性、溶胀性和机械性能方面也存在一些缺点。为了解决这些局限性，通过低强度紫外光照射法制备了基于聚乙二醇-共-聚己内酯（PEG-PCL）二丙烯酸酯大分子单体和羟丙基瓜尔胶（HPGG）的新型半互穿网络（semi-IPN）水凝胶，并通过傅里叶变换红外光谱（FT-IR）、差示扫描量热法（DSC）和广角X射线衍射（WAXD）分析对其进行了表征。通过研究溶胀动力学、动态力学流变学以及牛血清白蛋白（BSA）的释放行为对其性能进行了评估。结果发现，半互穿网络结构和HPGG的引入降低了水凝胶中PEG链段的结晶度，改善了水凝胶的溶胀性能和机械性能，同时降低了BSA从水凝胶中的释放百分比。这种水凝胶材料作为一种潜在的有趣的医疗器械设计平台可能具有更多优势。各种水凝胶样品的弹性模量（G'）和粘性模量（G''）随频率的变化。
