Cortelekoglu T, Bozkurt A K, Ustundag N, Koksal C, Sayin A G
Department of Cardiovascular Surgery, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.
Acta Chir Belg. 2006 Mar-Apr;106(2):206-10. doi: 10.1080/00015458.2006.11679872.
Neo-intimal hyperplasia is one of the most common causes of failure of arterial patency following cardiovascular interventions. It has been proposed that clopidogrel and calcium dobesilate may play an important role in the amelioration of intimal hyperplasia. The aim of this study is to examine the effect of these agents on intimal hyperplasia occurring after experimental balloon catheter injury.
Twenty-four male New Zealand rabbits were divided into three groups. Endothelial injury was caused by introducing a 2.5 x 20 mm balloon angioplasty-catheter into the left iliac artery. After the procedure, clopidogrel (25 mg/kg/day/orally) or calcium dobesilate (100 mg/kg/day/orally) were given for 2 weeks. Eight rabbits were given a placebo and served as controls. The contralateral non-injured iliac arteries of the control group were considered as normal iliac artery samples. Iliac artery specimens were examined planimetrically and the intima/media ratio was obtained for each vessel.
In the control group, the intima/media ratio was still significantly higher (p < 0.05) than the contralateral normal artery 14 days after the balloon catheter injury. In the clopidogrel and calcium dobesilate groups, this ratio had significantly decreased when compared with the control group (p < 0.05). No significant difference was found when the clopidogrel and calcium dobesilate groups were compared.
The anti-agregant agent clopidogrel, and the venous endothelial regulator calcium dobesilate, ameliorate intimal hyperplasia after experimentally induced vascular injury in rabbit iliac arteries.
新生内膜增生是心血管介入治疗后动脉通畅失败的最常见原因之一。有人提出氯吡格雷和羟苯磺酸钙可能在改善内膜增生方面发挥重要作用。本研究的目的是探讨这些药物对实验性球囊导管损伤后内膜增生的影响。
24只雄性新西兰兔分为三组。通过将一根2.5×20mm的球囊血管成形导管插入左髂动脉造成内皮损伤。术后，给予氯吡格雷（25mg/kg/天/口服）或羟苯磺酸钙（100mg/kg/天/口服），持续2周。8只兔子给予安慰剂作为对照。对照组对侧未受伤的髂动脉被视为正常髂动脉样本。对髂动脉标本进行平面测量，并获得每根血管的内膜/中膜比值。
对照组在球囊导管损伤14天后，内膜/中膜比值仍显著高于对侧正常动脉（p<0.05）。与对照组相比，氯吡格雷组和羟苯磺酸钙组的该比值显著降低（p<0.05）。氯吡格雷组和羟苯磺酸钙组之间未发现显著差异。
抗血小板药物氯吡格雷和静脉内皮调节剂羟苯磺酸钙可改善兔髂动脉实验性血管损伤后的内膜增生。
