Ruppert M, De Clerck L, van Offel J, Hubens G, Balliu L, Vaneerdeweg W
Department of Abdominal Surgery, University of Antwerp, Antwerp, Belgium.
Acta Chir Belg. 2006 Mar-Apr;106(2):225-7. doi: 10.1080/00015458.2006.11679877.
Vasculitis leading to intestinal necrosis is a rare complication of rheumatoid arthritis. The introduction of anti-TNF treatment for methotrexate-resistant cases improved disease-control substantially in these often more aggresive forms of rheumatoid arthritis. As far as we know only two cases of severe vasculitis following anti-TNF treatment have been reported. We describe a 45-year old female patient with severe rheumatoid arthritis, who presented with an epileptic insult, renal failure and a quickly deteriorating general condition due to intestinal vasculitis, while she had been receiving anti-TNF treatment for 6 months.
导致肠道坏死的血管炎是类风湿关节炎的一种罕见并发症。对于甲氨蝶呤耐药的病例，采用抗TNF治疗可显著改善这些通常更为侵袭性的类风湿关节炎的疾病控制情况。据我们所知，仅有两例抗TNF治疗后发生严重血管炎的病例报告。我们描述了一名45岁的重症类风湿关节炎女性患者，在接受抗TNF治疗6个月时，因肠道血管炎出现癫痫发作、肾衰竭及全身状况迅速恶化。
