Moriyama H, Kawahara K, Noguchi T, Kikuchi R, Wada S, Takeno S, Kashima K
Department of Oncological Science (Surgery II), Faculty of Medicine, The University of Oita, Oita, Japan.
J Exp Clin Cancer Res. 2006 Mar;25(1):129-34.
A case of primary extramedullary plasmacytoma of the small intestine in a 73-year-old Japanese woman was reported. The patient underwent local resection of the tumor, and showed no signs of local recurrence or dissemination of the disease after 28 months follow-up. The tumor cells had relatively large nuclei with distinct nucleoli and wide and slightly basophilic cytoplasm with a high N/C ratio which showed the morphology of atypical plasma cells. Immunohistochemical examination revealed that the tumor cells contained IgG gamma-type immunoglobulin in their cytoplasm but they did not contain IgA, IgM, IgD, and kappa-light chains. The tumor cells were also positive for CD79a and CD138 and negative for LCA, CD20 and CD45RO. These findings clearly indicated this case to be plasmacytoma.
报告了一例73岁日本女性小肠原发性髓外浆细胞瘤。患者接受了肿瘤局部切除，随访28个月后未出现疾病局部复发或播散迹象。肿瘤细胞具有相对较大的细胞核，核仁明显，胞质宽阔且略嗜碱性，核质比高，显示出非典型浆细胞的形态。免疫组织化学检查显示，肿瘤细胞胞质内含有IgGγ型免疫球蛋白，但不含有IgA、IgM、IgD和κ轻链。肿瘤细胞CD79a和CD138呈阳性，LCA、CD20和CD45RO呈阴性。这些发现明确表明该病例为浆细胞瘤。
