[通过使用D-苯丙氨酸增强对情绪压力的抵抗力]

[Enhanced resistance to emotional stress through the use of D-phenylalanine].

作者信息

Iumatov E A, Sarychev E I, Kozlovskiĭ I I, Mineeva M F, Demidov V M, Morozov I S, Kozlovskaia M M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1991 Jan-Feb;41(1):156-61.

Abstract

Stress-protective action was studied of D-phenylalanine, having an ability to decrease destruction of endogenic enkefalins. In the experiments stability of the experimental (receiving D-phenylalanine) and control groups of male rats of August line to emotional stress was compared in conditions of immobilization stress by parameters of animals survival rate, adrenal glands hypertrophy development, involution of thymus, pathologic changes in lungs (abscesses development), ulcero-dystrophic disturbances in stomach, and also the activity and kinetic properties of enzyme tyrosin-hydroxylase in the hypothalamus were determined. It was shown that by several of the mentioned physiological parameters the D-phenylalanine significantly increased the animals stability to the emotional stress and decreased tyrosinhydroxylase activity which participates in activation of katecholaminergic processes.

摘要

研究了具有降低内源性脑啡肽破坏能力的D-苯丙氨酸的应激保护作用。在实验中，通过动物存活率、肾上腺肥大发展、胸腺退化、肺部病理变化（脓肿发展）、胃部溃疡营养不良紊乱等参数，比较了八月龄雄性大鼠实验组（接受D-苯丙氨酸）和对照组在固定应激条件下对情绪应激的稳定性，还测定了下丘脑酪氨酸羟化酶的活性和动力学特性。结果表明，通过上述几个生理参数，D-苯丙氨酸显著提高了动物对情绪应激的稳定性，并降低了参与儿茶酚胺能过程激活的酪氨酸羟化酶活性。