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Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial.
Crit Care Med. 2003 Mar;31(3):834-40. doi: 10.1097/01.CCM.0000051515.56179.E1.
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Benefit-risk assessment of drotrecogin alfa (activated) in the treatment of sepsis.
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The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis.
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Is There NO Treatment For Severe Sepsis?
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Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.
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Activated protein C in sepsis: the promise of nonanticoagulant activated protein C.
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Effect of sepsis therapies on health-related quality of life.
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Benefit-risk assessment of drotrecogin alfa (activated) in the treatment of sepsis.
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本文引用的文献

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Intensive insulin therapy in the medical ICU.
N Engl J Med. 2006 Feb 2;354(5):449-61. doi: 10.1056/NEJMoa052521.
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Prescribing indications based on successful clinical trials in sepsis: a difficult exercise.
Crit Care Med. 2006 Feb;34(2):525-9. doi: 10.1097/01.ccm.0000198329.85851.8e.
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Drotrecogin alfa (activated) in severe sepsis.
N Engl J Med. 2006 Jan 5;354(1):94-6; author reply 94-6.
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Drotrecogin alfa (activated) in severe sepsis.
N Engl J Med. 2006 Jan 5;354(1):94-6; author reply 94-6. doi: 10.1056/NEJMc052759.
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Randomized trials stopped early for benefit: a systematic review.
JAMA. 2005 Nov 2;294(17):2203-9. doi: 10.1001/jama.294.17.2203.
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Activated protein C: do more survive?
Intensive Care Med. 2005 Dec;31(12):1624-6. doi: 10.1007/s00134-005-2829-4. Epub 2005 Oct 15.
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Reassessing recombinant human activated protein C for sepsis: time for a new randomized controlled trial.
Crit Care Med. 2005 Oct;33(10):2426-8. doi: 10.1097/01.ccm.0000183002.26587.ff.

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