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Crit Care. 2006;10(5):420. doi: 10.1186/cc5022.
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Drotrecogin alfa (activated) in severe sepsis.
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Drotrecogin alfa: a second look. More clinical trials in severe sepsis: mostly negative results.活化蛋白C：再审视。更多针对严重脓毒症的临床试验：大多为阴性结果。
Prescrire Int. 2007 Feb;16(87):7-9.
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Drotrecogin alfa (activated) in severe sepsis.
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Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis.为何临床医生不接受严重脓毒症关键临床试验的结果？一项贝叶斯分析。
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Drotrecogin alfa (activated) in patients with severe sepsis and a high risk of death.严重脓毒症且死亡风险高的患者使用活化蛋白C。
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本文引用的文献

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Activated protein C in sepsis: down but not out, yet.脓毒症中的活化蛋白C：虽已式微，但尚未出局。
Crit Care. 2006;10(4):416. doi: 10.1186/cc4988.
2
Drotrecogin alfa (activated): does current evidence support treatment for any patients with severe sepsis?活化蛋白C：目前的证据是否支持对任何严重脓毒症患者进行治疗？
Crit Care. 2006;10(3):145. doi: 10.1186/cc4947. Epub 2006 Jun 2.
3
Prescription of rh-APC differs substantially among western European countries.重组人活化蛋白C（rh-APC）在西欧各国的处方差异很大。
Intensive Care Med. 2006 Apr;32(4):630-1. doi: 10.1007/s00134-006-0075-z. Epub 2006 Mar 7.
4
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death.重组人活化蛋白C用于严重脓毒症且死亡风险较低的成人患者。
N Engl J Med. 2005 Sep 29;353(13):1332-41. doi: 10.1056/NEJMoa050935.
5
Drotrecogin alfa (activated) administration: too many subgroups.重组人活化蛋白C的给药：亚组过多。
Crit Care Med. 2003 Oct;31(10):2564; author reply 2564-5. doi: 10.1097/01.CCM.0000089929.73924.4C.
6
Measuring inconsistency in meta-analyses.评估荟萃分析中的异质性
BMJ. 2003 Sep 6;327(7414):557-60. doi: 10.1136/bmj.327.7414.557.
7
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis.重组人活化蛋白C在严重脓毒症患者重要临床亚组中的应用。
Crit Care Med. 2003 Jan;31(1):12-9. doi: 10.1097/00003246-200301000-00002.
8
Efficacy and safety of recombinant human activated protein C for severe sepsis.重组人活化蛋白C治疗严重脓毒症的疗效与安全性
N Engl J Med. 2001 Mar 8;344(10):699-709. doi: 10.1056/NEJM200103083441001.

Drotrecogin alfa (activated): down and not out, but not really in either.

作者信息

Friedrich Jan O, Adhikari Neill K J, Meade Maureen O

出版信息

Crit Care. 2006;10(5):420. doi: 10.1186/cc5022.

DOI:10.1186/cc5022
PMID:17029652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1751078/
Abstract
摘要