Zhang Hao, Yan Jian-hua, Wu Zhong-yao, Li Yong-ping
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Zhonghua Yan Ke Za Zhi. 2006 Apr;42(4):318-22.
Metastasis of nasopharyngeal carcinoma (NPC) to the orbit has been rarely known. We report 11 patients with metastasis of NPC to the orbit and discuss their clinical characteristics and prognosis.
Eleven patients with orbital metastasis of NPC who were seen between January 1, 1991 and December 31, 2003 in Zhongshan Ophthalmic Center, Sun Yat-sen University, were retrospectively reviewed.
Among 11 patients, there were nine males and two females. The mean age at diagnosis was 45.5 years. The left eye was involved in ten cases, and right eye in one. There were seven patients with a known history of NPC and four with no NPC history at the time of presentation. The seven patients with NPC history developed orbital metastasis at a mean time of 12.7 months (range 2.0 - 60.0 months) after the diagnosis of NPC. The mean duration of eye lesions at presentation was 10.3 months (range 0.7 - 36.0 months). Nine patients developed single metastatic focus and two patients had two foci in the affected orbit. The main component of the tumor was located in the nasal part of the orbit in eight cases, in the temporal part in two, and in the orbital apex in one. The anterior part of the orbit was affected in eight cases. The neoplasm was resected completely or partly through surgery. The diagnosis was histopathologically confirmed as NPC. Among them, four cases were squamous cell carcinomas, two cases lymphoepitheliomas, and five cases unclassified carcinomas. At the last following up examination, five patients had died as a result of disseminated metastasis, one patient had died of unknown cause and three were still alive with no active metastasis. Two patients had lost follow-up. The mean survival time after orbital diagnosis was 21 months.
NPC with orbital metastasis is rare. However, it is the most common primary cancer metastasizing to the orbit in our Center. Most of them were located in the anterior nasal part of the orbit. The prognosis of these metastasis cases is very poor.
鼻咽癌（NPC）转移至眼眶的情况鲜为人知。我们报告11例鼻咽癌转移至眼眶的患者，并讨论其临床特征及预后。
回顾性分析1991年1月1日至2003年12月31日期间在中山大学中山眼科中心就诊的11例鼻咽癌眼眶转移患者。
11例患者中，男性9例，女性2例。确诊时的平均年龄为45.5岁。10例累及左眼，1例累及右眼。7例患者有鼻咽癌病史，4例在就诊时无鼻咽癌病史。7例有鼻咽癌病史的患者在鼻咽癌诊断后平均12.7个月（范围2.0 - 60.0个月）出现眼眶转移。就诊时眼部病变的平均持续时间为10.3个月（范围0.7 - 36.0个月）。9例患者出现单个转移灶，2例患者在受累眼眶中有两个转移灶。肿瘤主要成分位于眼眶鼻侧8例，颞侧2例，眶尖1例。眼眶前部受累8例。通过手术对肿瘤进行了全部或部分切除。病理组织学确诊为鼻咽癌。其中，4例为鳞状细胞癌，2例为淋巴上皮瘤，5例为未分类癌。在最后一次随访检查时，5例患者因广泛转移死亡，1例患者死因不明，3例仍存活且无活动转移。2例患者失访。眼眶诊断后的平均生存时间为21个月。
鼻咽癌眼眶转移罕见。然而，在我们中心，它是转移至眼眶最常见的原发癌。大多数转移灶位于眼眶鼻前部。这些转移病例的预后非常差。
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