Iannella Nicolangelo, Tanaka Shigeru
Laboratory for Visual Neurocomputing, Brain Science Institute, RIKEN, 2-1 Hirosawa Wako-shi, Saitama 351-0198, Japan.
Neurosci Lett. 2006 Jul 31;403(1-2):24-9. doi: 10.1016/j.neulet.2006.03.079. Epub 2006 Jun 9.
The role of spike-timing-dependent plasticity (STDP) in shaping the strength of a synapse located on the dendritic tree has gained recent interest. Previous theoretical studies using STDP have mostly used simplified integrate-and-fire models to investigate the evolution of synaptic efficacy with time. Such studies usually show that the final weight distribution is unimodal or bimodal resulting from a multiplicative or additive STDP rule, respectively. However, very little is known about how STDP shapes the spatial organization of synaptic efficacies. Here, for the first time, we demonstrate that spatial clustering of synaptic efficacies can occur on the dendrite via STDP, where changes in synaptic efficacy are driven by timing differences between synaptic inputs and the generation of local dendritic spikes. Specifically, when the model neuron is stimulated by two independent groups of correlated afferent inputs, the synaptic efficacies from each group, are not only spatially clustered on the dendrite but also spatially complementary to each other.
尖峰时间依赖可塑性（STDP）在塑造位于树突树上的突触强度方面的作用最近引起了人们的关注。以前使用STDP的理论研究大多使用简化的积分发放模型来研究突触效能随时间的演变。这类研究通常表明，最终的权重分布分别是由乘法或加法STDP规则导致的单峰或双峰分布。然而，关于STDP如何塑造突触效能的空间组织，人们知之甚少。在这里，我们首次证明，通过STDP，突触效能的空间聚类可以在树突上发生，其中突触效能的变化是由突触输入与局部树突棘产生之间的时间差异驱动的。具体而言，当模型神经元受到两组独立的相关传入输入刺激时，每组的突触效能不仅在树突上在空间上聚类，而且在空间上相互补充。
