基于尖峰时间的突触可塑性:一个现象学框架。

Spike-timing dependent synaptic plasticity: a phenomenological framework.

作者信息

Kistler Werner M

机构信息

Department of Neuroscience, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands.

出版信息

Biol Cybern. 2002 Dec;87(5-6):416-27. doi: 10.1007/s00422-002-0359-5.

Abstract

In this paper a phenomenological model of spike-timing dependent synaptic plasticity (STDP) is developed that is based on a Volterra series-like expansion. Synaptic weight changes as a function of the relative timing of pre- and postsynaptic spikes are described by integral kernels that can easily be inferred from experimental data. The resulting weight dynamics can be stated in terms of statistical properties of pre- and postsynaptic spike trains. Generalizations to neurons that fire two different types of action potentials, such as cerebellar Purkinje cells where synaptic plasticity depends on correlations in two distinct presynaptic fibers, are discussed. We show that synaptic plasticity, together with strictly local bounds for the weights, can result in synaptic competition that is required for any form of pattern formation. This is illustrated by a concrete example where a single neuron equipped with STDP can selectively strengthen those synapses with presynaptic neurons that reliably deliver precisely timed spikes at the expense of other synapses which transmit spikes with a broad temporal distribution. Such a mechanism may be of vital importance for any neuronal system where information is coded in the timing of individual action potentials.

摘要

本文基于类似沃尔泰拉级数的展开式,建立了一种尖峰时间依赖型突触可塑性(STDP)的唯象模型。突触权重的变化作为突触前和突触后尖峰相对时间的函数,由积分核描述,这些积分核可以很容易地从实验数据中推断出来。由此产生的权重动态可以根据突触前和突触后尖峰序列的统计特性来表述。文中还讨论了对发放两种不同类型动作电位的神经元的推广,例如小脑浦肯野细胞,其突触可塑性取决于两条不同突触前纤维中的相关性。我们表明,突触可塑性与权重的严格局部界限一起,可导致任何形式的模式形成所需的突触竞争。这通过一个具体例子来说明,即配备STDP的单个神经元可以选择性地增强与突触前神经元的那些突触,这些突触前神经元可靠地传递精确计时的尖峰,而牺牲其他以广泛时间分布传递尖峰的突触。这种机制对于任何在单个动作电位的时间中编码信息的神经元系统可能至关重要。

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