Houghton JeanMarie, Morozov Alexei, Smirnova Iva, Wang Timothy C
Department of Medicine, GI Division, University of Massachusetts Medical School, LRB-Second Floor, Room 209, 364 Plantation Street, Worcester, MA 01605-2324, United States.
Semin Cancer Biol. 2007 Jun;17(3):191-203. doi: 10.1016/j.semcancer.2006.04.003. Epub 2006 May 4.
The cell of origin of cancer has been a strongly debated topic through out the history of cancer research. This review provides a historic framework and a synopsis of how the theories of cancer initiation and progression evolved from early times to the present day. We present the concept of a cancer stem cell, and review for you the literature supporting the existence of cancer stem cells in addition to a brief discussion on our own work supporting a bone marrow-derived source for the cancer stem cell, as well as cells of the cancer stroma.
癌症的起源细胞在癌症研究史上一直是一个备受争议的话题。本综述提供了一个历史框架，并概述了癌症起始和进展理论是如何从早期发展到如今的。我们提出了癌症干细胞的概念，并为您综述支持癌症干细胞存在的文献，此外还简要讨论了我们自己支持癌症干细胞来源于骨髓以及癌症基质细胞的研究工作。
