Zou Gang-Ming
Department of Pathology, Johns Hopkins University, Baltimore, Maryland 21231, USA.
J Cell Physiol. 2007 Nov;213(2):440-4. doi: 10.1002/jcp.21140.
The history of stem cell research was started in the early 1900s in Europe where the researcher realized that various types of blood cells came from a particular "stem cells." However, it was not until 1963 that the first quantitative description of the self-renewal activities of transplanted mouse bone marrow cells were documented by Canadian scientist Ernest A McCulloch and James E Till in Toronto. The concept of cancer stem cells has been used over 50 years ago; whereas the strong evidence for the existence of a Cancer Stem Cells was obtained recently. Consequently, there is increasing attention in recent year about cancer stem cells. The findings from recent studies support the concept that stem cells are integral to the development of several forms of human cancer. Changes in stem cell behavior can contribute to tumor formation. Leukemia is a cancer of blood-forming tissue, including the bone marrow and lymphatic system. Leukemic stem cells represent the cancer stem cells in the leukemia. In this review, we summarize the recent advance in the study of leukemic stem cells.
干细胞研究的历史始于20世纪初的欧洲，当时研究人员意识到各种类型的血细胞都来自特定的“干细胞”。然而，直到1963年，加拿大科学家欧内斯特·A·麦卡洛克和詹姆斯·E·蒂尔在多伦多才首次对移植的小鼠骨髓细胞的自我更新活动进行了定量描述。癌症干细胞的概念在50多年前就已被使用；而最近才获得了癌症干细胞存在的有力证据。因此，近年来人们对癌症干细胞的关注日益增加。最近的研究结果支持了干细胞是多种人类癌症发展不可或缺的一部分这一概念。干细胞行为的改变可能导致肿瘤形成。白血病是一种造血组织癌症，包括骨髓和淋巴系统。白血病干细胞代表了白血病中的癌症干细胞。在这篇综述中，我们总结了白血病干细胞研究的最新进展。
