Gonzalez-Quintela A, García J, Campos J, Perez L F, Alende M R, Otero E, Abdulkader I, Tomé S
Department of Internal Medicine, Complejo Hospitalario Universitario de Santiago, Spain.
Alcohol. 2006 Jan;38(1):45-9. doi: 10.1016/j.alcohol.2006.01.003.
Serum cytokeratin (CK) levels are widely used as tumor markers. Serum levels of CK-18, a tumor marker also known as tissue polypeptide specific antigen (TPS), are increased in patients with alcoholic liver disease. Cytokeratin-18 is the main component of Mallory bodies, a hallmark of alcoholic hepatitis, which may also contain CK-19. Serum levels of CK-18 and CK-19, a tumor marker also known as CYtokeratin FRAgment 21-1 (CYFRA 21-1) were investigated in (a) heavy drinkers with alcoholic liver disease (n=15), (b) patients with malignancy (n=22), and (c) healthy controls (n=10). Serum levels of CYFRA 21-1 (CK-19) were markedly increased in patients with malignancy, but were similar in heavy drinkers and healthy controls. In contrast, serum levels of TPS (CK-18) in heavy drinkers were higher than those of healthy controls, and even tended to be higher than those of patients with malignancy. Both CK-19 and CK-18 levels were higher in cases of alcoholic hepatitis than in cases of fatty liver. Correlation with hepatocyte CK inclusions was stronger for serum TPS (CK-18) than for CYFRA 21-1 (CK-19). In conclusion, serum CYFRA 21-1 (CK-19) and TPS (CK-18) show a different pattern of increase that could reflect the composition of the altered hepatocyte CK network in alcoholic liver disease. Their usefulness as tumor markers, particularly that of serum TPS (CK-18), may be limited in patients with alcoholic liver disease.
血清细胞角蛋白（CK）水平被广泛用作肿瘤标志物。血清CK-18水平，一种也被称为组织多肽特异性抗原（TPS）的肿瘤标志物，在酒精性肝病患者中升高。细胞角蛋白-18是马洛里小体的主要成分，酒精性肝炎的一个标志，其也可能含有CK-19。研究了（a）患有酒精性肝病的重度饮酒者（n = 15）、（b）恶性肿瘤患者（n = 22）和（c）健康对照者（n = 10）的血清CK-18和CK-19水平，CK-19是一种也被称为细胞角蛋白片段21-1（CYFRA 21-1）的肿瘤标志物。CYFRA 21-1（CK-19）的血清水平在恶性肿瘤患者中显著升高，但在重度饮酒者和健康对照者中相似。相反，重度饮酒者的血清TPS（CK-18）水平高于健康对照者，甚至有高于恶性肿瘤患者的趋势。酒精性肝炎患者的CK-19和CK-18水平均高于脂肪肝患者。血清TPS（CK-18）与肝细胞CK包涵体的相关性比CYFRA 21-1（CK-19）更强。总之，血清CYFRA 21-1（CK-19）和TPS（CK-18）呈现出不同的升高模式，这可能反映了酒精性肝病中改变的肝细胞CK网络的组成。它们作为肿瘤标志物的实用性，尤其是血清TPS（CK-18）的实用性，在酒精性肝病患者中可能有限。
