[慢性辅助增强型体外反搏猪模型的建立]
[Establishment of a pig model of chronic ally enhanced external counterpulsation].
作者信息
Chen Xiao-lin, He Xiao-hong, Zhang Yan, Qian Yue-tao, Liang Lu-guang, Fang Dian-qiu, Zhan Cheng-yang, Zheng Zhen-sheng, Ma Hong
机构信息
Department of Cardiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510089, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2006 May;26(5):613-4.
OBJECTIVE
To establish a pig model of chronic external counterpulsation.
METHODS
Twelve pigs were anaesthetized with sodium pentobarbital (< or =30 mg/kg.b.w.) and 846 mixture (< or =0.1 ml/kg.b.w.) and counterpulsed in a lateral position for 2 h every two days (totally 36 h) with 0.025 to 0.04 MPa/cm(2) pressure.
RESULTS
External counterpulsation was successfully completed in all the animals. Combined administration of sodium pentobarbital and 846 mixture resulted in good anesthetic effect with reduced anesthetic dosage and minimal side effect on the viscera (the liver, kidney and heart, etc).
CONCLUSION
The pig model of chronic external counterpulsation has been successfully established. Combined use of sodium pentobarbital and 846 mixture is recommended for chronic external counterpulsation.
目的
建立慢性体外反搏猪模型。
方法
12只猪用戊巴比妥钠（≤30毫克/千克体重）和846合剂（≤0.1毫升/千克体重）麻醉，侧卧，每两天反搏2小时（共36小时），压力为0.025至0.04兆帕/平方厘米。
结果
所有动物均成功完成体外反搏。戊巴比妥钠与846合剂联合应用麻醉效果良好，麻醉剂量减少，对内脏（肝、肾、心等）副作用最小。
结论
慢性体外反搏猪模型已成功建立。慢性体外反搏推荐联合使用戊巴比妥钠和846合剂。
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