动态对比增强磁共振成像中药代动力学参数的测定：造影剂浓度与信号强度之间非线性的影响
Determination of pharmacokinetic parameters in DCE MRI: Consequence of nonlinearity between contrast agent concentration and signal intensity.
作者信息
Heilmann Melanie, Kiessling Fabian, Enderlin Marta, Schad Lothar R
机构信息
Department of Medical Physics in Radiology, German Cancer Research Center (Deutsches Krebsforschungszentrum), Heidelberg, Germany.
出版信息
Invest Radiol. 2006 Jun;41(6):536-43. doi: 10.1097/01.rli.0000209607.99200.53.
OBJECTIVES
We sought to compare pharmacokinetic modeling of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data by assuming a linear and nonlinear relationship between signal intensity (SI) and contrast agent (CA) concentration.
MATERIALS AND METHODS
Data sets were generated by computer-based simulation studies and DCE-MRI examination of 5 tumor-bearing mice using a 1.5 T MR-scanner. Two approaches were investigated: a linear and nonlinear relationship between SI and CA concentration before pharmacokinetic analysis. In a pharmacokinetic 2-compartment model, values of exchange rate constant kep and amplitude A were compared for both assumptions.
RESULTS
In the linear approach, A was as much as 30% less for kep values between 1.0 and 5.0 min, whereas kep was as much as 60% greater, for kep between 0.2 and 5.0 min compared with the nonlinear one, as demonstrated in simulations and animal studies.
CONCLUSIONS
Nonlinearity between SI and CA concentration has to be considered for accurate parameter calculation in DCE-MRI studies.
目的
我们试图通过假设信号强度（SI）与造影剂（CA）浓度之间存在线性和非线性关系，来比较动态对比增强磁共振成像（DCE-MRI）数据的药代动力学模型。
材料与方法
通过基于计算机的模拟研究以及使用1.5 T MR扫描仪对5只荷瘤小鼠进行DCE-MRI检查来生成数据集。研究了两种方法：在药代动力学分析之前，SI与CA浓度之间的线性和非线性关系。在药代动力学双室模型中，比较了两种假设下的交换速率常数kep和幅度A的值。
结果
在模拟和动物研究中表明，在线性方法中，对于1.0至5.0分钟之间的kep值，A比非线性方法少多达30%，而对于0.2至5.0分钟之间的kep，kep比非线性方法大多达60%。
结论
在DCE-MRI研究中，为了准确计算参数，必须考虑SI与CA浓度之间的非线性关系。
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