Tandon N, Zhang L, Weetman A P
Department of Medicine, University of Cambridge Clinical School, UK.
Clin Endocrinol (Oxf). 1991 May;34(5):383-6. doi: 10.1111/j.1365-2265.1991.tb00309.x.
There is disagreement over the HLA-DR associations of Hashimoto's (goitrous) thyroiditis. We have studied 86 English Caucasian patients with this condition whose DR types were determined by restriction fragment polymorphism analysis. HLA-DR3 was significantly more frequent in these patients than in 100 controls (chi 2 = 7.09; P less than 0.01). The relative risk was 2.23 and aetiological fraction 0.29. HLA-DPB and DQB alleles were analysed in a proportion of these subjects by enzymatic DNA amplification and oligonucleotide probing. The only significant finding was an excess of HLA-DQw2 (in linkage disequilibrium with DR3) in the Hashimoto group (chi 2 = 7.43, P less than 0.007). These results do not support a difference between goitrous and atrophic thyroiditis based on respective associations with HLA-DR5 and DR3, but confirm a recent study in which HLA-DR3 was associated with Hashimoto's thyroiditis. However, it is possible that genes telomeric to DR3 may be involved in determining which type of thyroiditis a patient with autoimmune hypothyroidism develops.
关于桥本（甲状腺肿性）甲状腺炎与HLA - DR的关联存在争议。我们研究了86例患有这种疾病的英国白种人患者，通过限制性片段多态性分析确定了他们的DR类型。这些患者中HLA - DR3的出现频率显著高于100名对照者（卡方 = 7.09；P小于0.01）。相对风险为2.23，病因分数为0.29。通过酶促DNA扩增和寡核苷酸探针分析了部分这些受试者的HLA - DPB和DQB等位基因。唯一显著的发现是桥本组中HLA - DQw2（与DR3处于连锁不平衡）过量（卡方 = 7.43，P小于0.007）。这些结果不支持基于与HLA - DR5和DR3的各自关联而得出的甲状腺肿性甲状腺炎和萎缩性甲状腺炎之间存在差异的观点，但证实了最近一项研究中HLA - DR3与桥本甲状腺炎相关。然而，有可能DR3端粒的基因参与决定自身免疫性甲状腺功能减退患者会发展为何种类型的甲状腺炎。
