Stenszky V, Balázs C, Kraszits E, Juhasz F, Kozma L, Balázs G, Farid N R
Blood Transfusion Center, Medical University, Debrecen, Hungary.
J Immunogenet. 1987 Apr-Jun;14(2-3):143-8. doi: 10.1111/j.1744-313x.1987.tb00374.x.
An association of HLA-DR5 and goitrous autoimmune thyroiditis has been reported elsewhere (Farid et al., 1981; Weissel et al., 1980). Recently, the disease was found to be associated with HLA-DR4 in Newfoundlanders (Farid & Thompson, 1986). In order to find out whether different HLA associations with the disease may be found in different ethnic groups, we have now typed 68 patients with autoimmune goitrous thyroiditis from Eastern Hungary for HLA-A, -B, -C, and -DR antigens; 66 of these patients were also typed for IgG heavy-chain markers (Gm). A significant increase in DR3 (OR = 3.30) and a non-significant increase in DR4 (OR = 1.67) were found in the patients when compared with controls. The Gm3 allele, g, interacted with DR3 to enhance the risk for goitrous autoimmune thyroiditis. Hashimoto's disease may show different associations in different ethnic groups, and indeed within the same ethnic group, when newly diagnosed patients are typed several years apart.
其他地方已有关于HLA - DR5与甲状腺肿性自身免疫性甲状腺炎相关性的报道（法里德等人，1981年；魏塞尔等人，1980年）。最近，在纽芬兰人中发现该疾病与HLA - DR4相关（法里德和汤普森，1986年）。为了弄清楚在不同种族群体中是否会发现该疾病与不同的HLA相关，我们现在对来自匈牙利东部的68例自身免疫性甲状腺肿性甲状腺炎患者进行了HLA - A、- B、- C和 - DR抗原分型；其中66例患者还进行了IgG重链标记（Gm）分型。与对照组相比，患者中DR3显著增加（比值比=3.30），DR4非显著增加（比值比=1.67）。Gm3等位基因g与DR3相互作用，增加了甲状腺肿性自身免疫性甲状腺炎的发病风险。桥本氏病在不同种族群体中可能表现出不同的相关性，实际上在同一种族群体中，当相隔数年对新诊断患者进行分型时也会如此。
