Donadio Vincenzo, Liguori Rocco, Vetrugno Roberto, Elam Mikael, Falzone Francesca, Baruzzi Agostino, Montagna Pasquale
Dept. of Neurological Sciences, University of Bologna, Bologna, Italy.
Clin Auton Res. 2006 Jun;16(3):235-9. doi: 10.1007/s10286-006-0346-3. Epub 2006 May 12.
Studies comparing the efficacy of continuous positive airway pressure (CPAP) versus surgery in correcting cardiovascular abnormalities in OSAS are lacking. We describe an OSAS patient with hypertension who responded favorably to CPAP treatment, whereas subsequent uvulopalatopharyngoplasty (UPPP) was less successful. While CPAP markedly lowered daytime muscle sympathetic nerve activity (MSNA) and blood pressure (BP), findings after UPPP were comparable to pre-treatment baseline. Thus, parallel changes in MSNA and BP demonstrated treatment efficacy.
缺乏比较持续气道正压通气（CPAP）与手术矫正阻塞性睡眠呼吸暂停低通气综合征（OSAS）心血管异常疗效的研究。我们描述了一名患有高血压的OSAS患者，该患者对CPAP治疗反应良好，而随后的悬雍垂腭咽成形术（UPPP）效果欠佳。CPAP能显著降低日间肌肉交感神经活动（MSNA）和血压（BP），而UPPP术后的结果与治疗前基线水平相当。因此，MSNA和BP的平行变化证明了治疗效果。
