Pigeot I, Ahrens W, Kübler J
Bremer Institut für Präventionsforschung und Sozialmedizin (BIPS), Linzer Strsse 10, 28359 Bremen.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2006 Jul;49(7):628-36. doi: 10.1007/s00103-006-1290-z.
The use of large databases has a high potential for future epidemiological research. Databases consisting of primary data as well as routine data that are mainly collected for administrative purposes will be of interest. This paper presents some large databases and some that are most relevant for epidemiological research, respectively, and shows how they might be exploited for research purposes. To make better use of large databases there are new requirements and challenges that we have to face regarding appropriate methods for their analysis. Some examples of such methods are given. An example of pharmaco-epidemiology illustrates linkage of several administrative databases and specific problems that have to be solved in this context. Finally, future challenges are discussed that have to be overcome on the way towards establishment, maintenance and analysis of large databases, especially regarding data protection, data quality and regular updates.
大型数据库的应用在未来流行病学研究中具有巨大潜力。由主要为行政目的收集的原始数据以及常规数据组成的数据库将备受关注。本文分别介绍了一些大型数据库以及一些与流行病学研究最相关的数据库，并展示了如何将它们用于研究目的。为了更好地利用大型数据库，在其分析的适当方法方面，我们必须面对新的要求和挑战。文中给出了一些此类方法的示例。药物流行病学的一个例子说明了几个行政数据库的链接以及在此背景下必须解决的具体问题。最后，讨论了在大型数据库的建立、维护和分析过程中必须克服的未来挑战，特别是在数据保护、数据质量和定期更新方面。
