Gronchi-Perrin Aline, Viollier Sarah, Ghika Joseph, Combremont Pierre, Villemure Jean-Guy, Bogousslavsky Julien, Burkhard Pierre R, Vingerhoets François
Vaud-Geneva Deep Brain Stimulation Program for Movement Disorders, CHUV, Lausanne, Switzerland.
Mov Disord. 2006 Sep;21(9):1465-8. doi: 10.1002/mds.20943.
We investigated the impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on quality of life (QOL) in patients with advanced Parkinson's disease, as self-assessed before and after surgery by completing the Parkinson's Disease Questionnaire (PDQ39). In addition to this prospective evaluation, we asked patients postoperatively to evaluate their preoperative QOL. In the prospective assessment, results showed that patients perceived a general improvement of QOL after the STN DBS. However, when evaluated retrospectively, they tended to overestimate their preoperative functioning, therefore obscuring the improvement found prospectively. This observation highlights the impact of the method used on obtained results when assessing the effects of STN DBS.
我们通过让晚期帕金森病患者在手术前后完成帕金森病问卷（PDQ39）进行自我评估，研究了丘脑底核（STN）深部脑刺激（DBS）对患者生活质量（QOL）的影响。除了这一前瞻性评估外，我们还让患者在术后评估其术前的生活质量。在前瞻性评估中，结果显示患者在接受STN DBS后生活质量总体有所改善。然而，在进行回顾性评估时，他们往往高估了自己术前的功能，从而掩盖了前瞻性研究中发现的改善情况。这一观察结果突出了在评估STN DBS效果时所采用的方法对所得结果的影响。
