Umemura Atsushi, Toyoda Takanari, Yamamoto Kenichi, Oka Yuichi, Ishii Fumiyasu, Yamada Kazuo
Department of Neurosurgery, Nagoya City University Medical School, 1 Kawasumi, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.
Parkinsonism Relat Disord. 2008 Dec;14(8):655-7. doi: 10.1016/j.parkreldis.2007.12.008. Epub 2008 Mar 3.
Apraxia of eyelid opening (ALO) is an infrequent side effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD). However, the pathogenesis of ALO after STN DBS is not well understood. We report on two patients who suffered from disabling ALO after bilateral STN DBS. Their ALO improved by resuming the levodopa medication that had been discontinued after the surgery. Although ALO after STN DBS is considered as an adverse effect of STN stimulation, postoperative modification of dopaminergic medication may be a cause of ALO after STN DBS.
眼睑开合失用症（ALO）是丘脑底核（STN）深部脑刺激（DBS）治疗帕金森病（PD）时一种罕见的副作用。然而，STN-DBS术后ALO的发病机制尚不清楚。我们报告了两名双侧STN-DBS术后出现严重ALO的患者。通过恢复术后停用的左旋多巴药物治疗，他们的ALO症状得到改善。尽管STN-DBS术后的ALO被认为是STN刺激的不良反应，但术后多巴胺能药物的调整可能是STN-DBS术后ALO的一个原因。
