Sato Kenichi, Hatano Taku, Yamashiro Kazuo, Kagohashi Maki, Nishioka Kenya, Izawa Nana, Mochizuki Hideki, Hattori Nobutaka, Mori Hideo, Mizuno Yoshikuni
Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan.
Mov Disord. 2006 Sep;21(9):1384-95. doi: 10.1002/mds.20993.
We report a long-term outcome on a large cohort of Japanese patients with Parkinson's disease (PD). A total of 1,768 (793 men, 975 women) consecutive patients visited our clinic from 1 January 1989 to 31 December 2002. Among them, 1,183 patients (531 men, 652 women) came to our clinic within 5 years from the onset of disease and at the Hoehn & Yahr Stage III or less at the first visit. Long-term outcome was evaluated in this subcohort of the patients. We examined the duration to reach Stage III, IV, and V, and the duration to develop wearing off and dyskinesia. Time to reach Stage III was slightly but significantly shorter in women, in that 23.8% of men and 35.3% of women reached Stage III by the end of the 5th year; 49.7% of men and 63.3% of women reached Stage III by the end of the 10th year, and 88.9% of men and 79.9% of women by the end of the 15th year (P < 0.001). Also, durations to develop wearing off and dyskinesia were shorter in women compared to men. These data suggest that the disease progression may be slightly faster for women. Young-onset patients showed significantly longer duration to reach Stage III, IV, and V but shorter duration to develop wearing off and dyskinesia. Not many studies are available in the literature on the long-term outcome of PD, and our data would be useful as a reference.
我们报告了一大群日本帕金森病（PD）患者的长期预后情况。从1989年1月1日至2002年12月31日，共有1768名（793名男性，975名女性）连续就诊的患者来到我们诊所。其中，1183名患者（531名男性，652名女性）在疾病发病后5年内来到我们诊所，且首次就诊时处于Hoehn & Yahr III期或更低分期。对该亚组患者的长期预后进行了评估。我们检查了达到III期、IV期和V期的时间，以及出现剂末现象和异动症的时间。女性达到III期的时间略短但具有显著差异，即到第5年末，23.8%的男性和35.3%的女性达到III期；到第10年末，49.7%的男性和63.3%的女性达到III期；到第15年末，88.9%的男性和79.9%的女性达到III期（P<0.001）。此外，女性出现剂末现象和异动症的时间比男性短。这些数据表明女性的疾病进展可能略快。年轻发病的患者达到III期、IV期和V期的时间显著更长，但出现剂末现象和异动症的时间更短。关于PD长期预后的文献研究不多，我们的数据将作为参考很有用。
