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肥大细胞和嗜碱性粒细胞上有效IgE交联的要求。

Requirements for effective IgE cross-linking on mast cells and basophils.

作者信息

Knol Edward F

机构信息

Department of Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

Mol Nutr Food Res. 2006 Jul;50(7):620-4. doi: 10.1002/mnfr.200500272.

DOI:10.1002/mnfr.200500272
PMID:16764017
Abstract

This article reviews the characteristics of high affinity IgE receptors (FcepsilonRI) and their role in the response to allergenic proteins. The requirements for successful cross-linking of FcepsilonRI on basophils and mast cells and subsequent degranulation by allergenic proteins will be explained in detail. Methods for in vitro analysis of allergen-induced mast cell and basophil degranulation will be described and issues/problems in applying these methods will be discussed. Finally, implications for manipulation of protein allergens will be discussed.

摘要

本文综述了高亲和力IgE受体（FcepsilonRI）的特性及其在对变应原性蛋白反应中的作用。将详细解释变应原性蛋白成功交联嗜碱性粒细胞和肥大细胞上的FcepsilonRI以及随后脱颗粒的条件。将描述变应原诱导的肥大细胞和嗜碱性粒细胞脱颗粒的体外分析方法，并讨论应用这些方法时的问题。最后，将讨论对蛋白变应原进行操控的意义。

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