用于从动物细胞生产生物制药的生物反应器系统。

Bioreactor systems for the production of biopharmaceuticals from animal cells.

作者信息

Warnock James N, Al-Rubeai Mohamed

机构信息

Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, 39762, USA.

出版信息

Biotechnol Appl Biochem. 2006 Jul;45(Pt 1):1-12. doi: 10.1042/BA20050233.

DOI:10.1042/BA20050233

PMID:16764553

Abstract

The demand for biopharmaceutical products is set to see a significant increase over the next few years. As a consequence, the processes used to produce these products must be able to meet market requirements. The present paper reviews the current technologies available for animal cell culture and highlights the advantages and disadvantages of each method, while also providing details of recent case studies. Processes are described for both suspension and anchorage-dependent cell lines.

摘要

未来几年，对生物制药产品的需求预计将大幅增长。因此，用于生产这些产品的工艺必须能够满足市场需求。本文综述了目前可用于动物细胞培养的技术，强调了每种方法的优缺点，同时还提供了近期案例研究的详细信息。文中描述了悬浮细胞系和贴壁依赖性细胞系的培养过程。