Wang L-Y, Liang D-C, Liu H-C, Chang F-C, Wang C-L, Chan Y-S, Lin M
Division of Pediatric Hematology-Oncology, Mackay Memorial Hospital, Taipei, Taiwan.
Transfus Med. 2006 Jun;16(3):200-3. doi: 10.1111/j.1365-3148.2006.00656.x.
The development of erythrocyte alloantibodies complicates transfusion therapy in patients with thalassemia. However, no data are available on the frequency of erythrocyte alloimmunization in patients with transfusion-dependent thalassemia in Taiwan. We analysed the clinical and transfusion records of 30 individuals (15 females and 15 males; mean age, 20 years; range, 4-31 years) with thalassemia who had regular transfusions for periods ranging from 0.5 to 20 years. Of the 30 patients, 28 who had beta-thalassemia major and two who had Hb H disease (alpha thalassemia), 11 (37%) were found to carry alloantibodies. All alloantibodies were clinically significant specificities, including four cases of anti-E, two of anti-E + c, two of anti-'Mi(a)', one of anti-'Mi(a)' + E, one of anti-D and one of anti-S. Alloimmunization to erythrocyte antigens is a frequent complication in transfusion-dependent thalassemia.
红细胞同种抗体的产生使地中海贫血患者的输血治疗变得复杂。然而，台湾地区依赖输血的地中海贫血患者红细胞同种免疫的频率尚无相关数据。我们分析了30例地中海贫血患者（15名女性和15名男性；平均年龄20岁；范围4 - 31岁）的临床和输血记录，这些患者定期输血0.5至20年。在这30例患者中，28例为重型β地中海贫血，2例为Hb H病（α地中海贫血），发现11例（37%）携带同种抗体。所有同种抗体均具有临床意义，包括4例抗 - E、2例抗 - E + c、2例抗 - “Mi(a)”、1例抗 - “Mi(a)” + E、1例抗 - D和1例抗 - S。红细胞抗原的同种免疫是依赖输血的地中海贫血患者常见的并发症。
